The enhancement of Nrf2-dependent glycolysis and glutathione synthesis was involved in the development of radioresistance. Moreover, elevated Nrf2 expression was associated with radioresistance. Nrf2 was stably upregulated in CRR cells in vitro and in a mouse xenograft model. Immunohistochemistry of phosphorylated Nrf2 (p-Nrf2) was performed in 110 patients with OSCC who underwent preoperative chemoradiotherapy and surgery. The effects of Nrf2 downregulation on radiosensitivity and the involvement of glycolysis in Nrf2-mediated radioresistance were evaluated. Two OSCC cell lines (SAS and HSC-2) and their clinically relevant radioresistant (CRR) clones (SAS-R, HSC-2-R) were used. However, little is known about the association between Nrf2 and radioresistance in OSCC. Resistance to radiotherapy is a major obstacle in treating oral squamous cell carcinoma (OSCC). ![]() Nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of critical antioxidant proteins, was recently demonstrated to play a key role in cancer progression.
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